ABSTRACT
Objective To evaluate the clinical values of serum soluble CD44 (solCD44) in diagnostic classification of acute myeloid leukemia (AML).Methods 80 patients with AML who admitted in Department of Hematology in our hospital from January 2014 to January 2016 were enrolled.Among these 80 cases,there were 31 cases newly diagnosed,24 cases refractory and 25 cases remission.40 healthy volunteers were set as the control group.The levels of solCD44s,solCD44v5 and solCD44v6 were measured and compared of each group.Results The levels of serum solCD44s,solCD44v5 and solCD44v6 in newly diagnosed and refractory group of AML patients were significantly higher than those in the control group and remission group (P0.05);There were significant differences of serum levels of solCD44s,solCD44v5,solCD44v6 in different FAB subgroups (M1+M2),M3,M4 and M5,meanwhile,the serum levels of solCD44s,solCD44v5,solCD44v6 in M3 type were significantly higher than those in non-M3 type (P<0.05).Conclusion The level of solCD44 especially solCD44std is closely related to the changes of disease activity in patients with AML.Serum solCD44 levels can be used as serological reference indicators of diagnostic classification,prognosis and recurrence prediction for AML.